A Maryland native, Mary Jenkins attended a Sisters of Charity school, where she converted to Catholicism. She married John Surratt in 1840. After her husband's death, she operated a boardinghouse, through which she came to know John Wilkes Booth. She was convicted as one of the conspirators in the assassination of President Abraham Lincoln in 1865 (along with another Catholic, Samuel Mudd) and sentenced to death by hanging.